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Grey's Anatomy's Sara Ramirez: Callie/Arizona Are 'Back to Step 1' After 'Devastating' Showdown

Grey's Anatomy Season 10 CalzonaFor Grey’s Anatomy‘s Callie and Arizona, last season marked 23 steps forward and then one huge step back.

Yes, the forever-tested twosome gradually found their footing after Callie ignored Arizona’s wishes and amputated one of her wife’s legs in the wake of the plane crash. But then in the season finale, everything the couple built came crashing down when Arizona’s impetuous indiscretion with Dr. Lauren Boswell was outed.

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“It was just devastating. Heartbreaking,” Sara Ramirez recalls of the gut-punch Callie sustained. “I mean, it’s everything you don’t want to have happen, for anyone.” (Revisit Arizona’s outburst scene, then read on.)

Adding insult to emotional injury: For Callie, this was the second time someone she was wed to cheated on her. (Thanks, George! Oh, and R.I.P.) As such, series creator Shonda Rhimes says, “Callie has got some stuff to deal with” — as does her Mrs. “Arizona’s not necessarily holding a grudge because Callie cut off her leg; that’s not really what it’s about,” Rhimes teases. “She got over [that] and sort of moved on, but never dealt with any of the underlying issues. There has to be something else going on there.”

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While you mull that mystery, here’s what we do know: As Season 10 opens (with a two-hour premiere airing Sept. 26), barely any time has passed since the events of the superstorm-soaked finale, and the doctors of Grey+Sloan Memorial are now receiving the casualties of a resultant mudslide. And that’s on top of the assorted emotional storms still brewing indoors.

“Callie’s reeling from hearing that her wife is still very, very angry and hurt,” Ramirez shares. “So essentially they regress back to Step 1, to where they started in Season 9. It’s like, ‘Ugh, we’re back at the beginning,’ so there is a lot of work that needs to be done.”

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But while these two doctors can work miracles reassembling bone or repairing tiny humans, Ramirez is uncertain if they have what it takes to recuperate from this double whammy of infidelity and resurfaced resentment.

“We’re going to see in the first few episodes Callie being reactive and acting out, dealing with her own feelings about what’s happening,” Ramirez says. And she won’t necessarily leave this volatile matter behind closed on-call room doors.

“Callie doesn’t hide it from the hospital, how she’s feeling,” Ramirez reveals with a small chuckle. “No, she lets it be known!”

Want more scoop on Grey’s, or for any other show? Email insideline@tvline.com and your question may be answered via Matt’s Inside Line.