Grey's Anatomy First Look: Neve Campbell Checks In as Derek's Sister!

Grey's Anatomy Neve Campbell Season 9 Derek's SisterAnother branch on the Shepherd family tree will be identified on Dec. 6 when Neve Campbell makes her Grey’s Anatomy debut as Derek’s previously unnamed fourth sister Lizzie — and we’ve got a first look at the Party of Five star’s arrival.

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It’s not clear what triggers Lizzie’s appearance, but the family reunion comes as the doctors at Seattle Grace (namely, Callie) face mounting pressure to fix Derek’s injured hand.

For the record, Campbell’s Lizzie brings to three the number of Shepherd sisters viewers have met, joining Amelia (currently played by Caterina Scorsone on Private Practice) and Nancy (previously played by Embeth Davitz). Might we meet Sibling No. 4 — the mysterious Kathleen the psychiatrist — before the season ends?

Scroll down to take a peek at a second image from Campbell’s debut episode and then hit the comments with your thoughts/theories.