The Emmy winner will play Avery Ryan, Special Agent in Charge at the Cyber Crime Division of the FBI in Quantico, VA. Ryan is tasked with solving high-octane crimes that start in the mind, live on-line, and play out into the real world.
The character, inspired by real-life Cyber Psychologist Mary Aiken (who serves as a producer), will be introduced in an episode of CSI: Original Flavor to air later this season. (CBS will decide whether to order the spin-off to series in May.)
Franchise creator Anthony E. Zuiker will co-write the script with longtime CSI EPs Carol Mendelsohn and Ann Donahue.
Arquette most recently recurred on the fifth season of Boardwalk Empire as a love interest for Steve Buscemi’s Nucky Thompson.