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Exclusive: Will & Grace Reunion on Sean Saves the World, Megan Mullally to Play Sean's [Spoiler]

Sean Saves the World Megan MullallyPolish the martini glasses — and make sure there’s enough vodka to fill ’em: Jack and Karen are reuniting.

Megan Mullally has signed on to appear alongside her Will & Grace sidekick Sean Hayes in an upcoming episode of his rookie NBC comedy Sean Saves the World, TVLine has learned exclusively.

And this time around, their alter egos literally share the same DNA.

Sources confirm that Mullally will play the sister of Hayes’ character in this season’s 17th episode, which shoots in early February.

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This marks Hayes and Mullally’s first onscreen reunion since Will & Grace ended its Peacock run nearly a decade ago.

The modestly-rated Sean was recently picked up for five additional episodes, bringing its Season 1 total to 18. A new episode airs this Thursday at 9/8c.