Bones + Family Guy

Unlike the Bones/Sleepy Hollow crossover, this extremely unexpected pairing actually did make sense in the context of the episode, which found Booth having hallucinations of Stewie Griffin (voiced by Seth MacFarlane). The taunting cartoon character even showed up during an interrogation scene to mock Booth and Brennan’s suspect and push Booth toward a vocal epiphany. Naturally, the outburst prompted concern from Brennan, after which it was revealed that Booth was suffering from a brain tumor. (Bones Season 4, Episode 24)