"Love is a Mixtape" — After spending the summer apart with Dana and unsure of their relationship, Adam makes a mixtape to express his feelings… only to have it intercepted by Beverly who thinks it's meant for her! Adam must carefully navigate not hurting Beverly's feelings as his relationship with Dana progresses. Meanwhile, Barry gets a fake ID, but after showing it off to the entire school, it's confiscated, and Barry needs to make good on some promises he made to his classmates.
"I Must Have Lost It On The Wind" — With Cristina gone, a new doctor, Maggie Pierce (Kelly McCreary), making the rounds and Derek wanting to move to Washington DC, Meredith struggles to regain a sense of normalcy both at home and in the hospital. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina's board seat and a freak accident causes two teenagers to be caught in a very compromising position.
MARVEL’S AGENTS OF S.H.I.E.L.D.
“Shadows” – Coulson and his team are now wanted fugitives with limited resources — but that’s not stopping them from keeping the world safe from powerful and unseen threats everywhere. However, with new members they hardly know, will S.H.I.E.L.D. ever be trusted again?
The guest star roster for the premiere, meanwhile, includes Hayley Atwell (as Peggy Carter, the focus of ABC’s midseason <I> Agent Carter</i>) and newsman George Stephanopoulos.
"Unbraceable You" — Frankie makes a giant blunder when she discovers that school started a week earlier than she thought, and Sue and Brick must scramble to catch up on the days they’ve missed and re-acclimate themselves to school life. Meanwhile, it looks like the "Year of Sue" might be starting off on a high when she finally gets her braces removed. Axl beats Mike at basketball for the first time in his life, and Brick gets creative in an attempt to find the perfect school book bag.
"That's Me Without You" — In the uniquely structured season premiere, a torn Rayna must choose not just between two men, but two directions that her life could take. Juliette, struggling to repair her relationship with Avery, auditions for the leading role of a film biopic. Meanwhile, Scarlett, determined to start fresh, embarks on a road trip home and bonds with an unexpected stowaway, and Will and Layla manage the fallout from his on-camera confession.
ONCE UPON A TIME
"A Tale of Two Sisters" — A scared and confused Elsa finds herself in Storybrooke and, fearful of the intentions of its residents, creates a powerful snow monster for protection. With Robin Hood's wife, Marian, back in the picture, Regina wonders if her "happily ever after" with the former thief has been completely quashed; while on their honeymoon, Mr. Gold finds an intriguing object that makes him question whether or not he should officially give Belle control over the dagger that makes him The Dark One, and Hook is dismayed to discover that Emma seems to be avoiding him while she tries to help comfort Regina after being the one responsible for bringing Marian back from the past and into Storybrooke. Meanwhile, in Arendelle of the past, as Elsa's sister Anna's wedding to Kristoff nears, Anna discovers that their parents – who died on-ship during a violent storm – were heading to a mysterious destination in a quest that may have held the secret to containing Elsa's out of control Ice powers. And against Elsa's wishes, Anna wants to finish their journey to find out what they were looking for.
"Revelation" — Bellamy awakens alone and abandoned at Arcadia's outskirts, missing a week of his life. As his memory returns, he has a shocking revelation. Meanwhile, Arcadia welcomes one more returned, Margaret Langston (Game of Thrones‘ Michelle Fairley), the powerful matriarch of the Langston family, dead for over three decades.
"Renaissance" — As Emily plans to host her most surprising party ever, Victoria finds a way to turn her greatest setback into a dangerous advantage. Meanwhile, unbeknownst to them both, David Clarke plans his next move.
"Randy, Red, Superfreak and Julia" — Nearly two months after Olivia and Jake boarded a private jet to stand in the sun together, everything has changed. With another four years in the White House, Fitz and Cyrus are doing everything they can to make a positive impact on the nation. Meanwhile, Mellie struggles to cope with the loss of her son and the gladiators feel the impact of Olivia's absence.