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Grey's: The 20 Saddest Deaths, Ranked

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Another one bites the dust. No sooner had Grey’s Anatomy returned from its winter break with Thursday’s midseason premiere than ABC’s long-running medical drama had sent a new casualty from the O.R. to the morgue: Giacomo Gianniotti’s Dr. Andrew DeLuca. (Read the actor’s take on his grim on-screen fate here and why showrunner Krista Vernoff killed him off here.)

If you’re still reeling, you’re not alone; just take a gander at the plentiful comments that have been left beneath the episode’s recap. But we may have found a creative way to to alleviate all of our sorrow — by reliving the show’s 20 most heartbreaking deaths ever to put this latest one in perspective.

Hey, we didn’t say that it was going to be easy.

Included in our tear-soaked list of crushing casualties are the demises of not only major Grey’s Anatomy McPlayers like Derek Shepherd and George O’Malley but also a couple of special guest characters who made a big (as well as a lasting) impression without even surviving to see a second episode. And no, we’re not going to give you any hints about their identities; to see which of the departed we considered to be the dearest, you’re going to have to be brave and scroll through all the photos.

So, tissues at the ready? Click on the above gallery to begin your bittersweet walk down Memory Lane, then hit the comments with any swan songs that we omitted that you think we had to have been brain-dead not to have included.