Arquette’s resume also included the films Threesome (1994) and The Wedding Singer (1998), the latter of which found her playing a Boy George impersonator, as well as Season 6 of VH1’s reality show The Surreal Life.
Arquette, the sister of actors Rosanna, Patricia and David, lent visibility to the transgender community long before Caitlyn Jenner arrived on the scene. She documented her transition from male to female in the 2007 film Alexis Arquette: She’s My Brother.
An exact cause of death is not known, but she reportedly had been battling an illness.
Thank you all for your love and kind words about Alexis. My hero for eternity pic.twitter.com/Z18xLtYTBv
— David Arquette (@DavidArquette) September 11, 2016
My heart goes out to anyone who was lucky enough to know Alexis.
We will love and miss you forever.
— Courteney Cox (@CourteneyCox) September 11, 2016
R.I.P my sister Alexis Arquette. Another bright light gone out far too soon. Love to the family and all that loved Alexis.
— Boy George (@BoyGeorge) September 11, 2016