In the Disney XD series’ “Lost in Danville” episode — with story by Lost cocreator Damon Lindelof and airing Monday, Sept. 29 at 7:30/6:30c, 10 years-plus-one week after ABC’s supernatural drama debuted — a mysterious capsule falls into Phineas and Ferb’s back yard and they struggle to open it.
Meanwhile, as seen in the clip above, Dr. Doofenshmirtz is abducted by another evil scientist, Professor Mystery (voiced by O’Quinn), who has his own sinister plan and -inator device — as well as an out-of-place bear for a Perry-like adversary.
Other guest voices include Rob Morrow (the Numb3rs!!!!) and Jane Kaczmarek (Malcolm in the Middle), as capsule inhabitants
Desmond and Penny Denise and Bernie.