The When Harry Met Sally star is looking to return to television as the star of an NBC comedy, our sister site Deadline reports.
In the single-camera project, now being developed by the network and Universal TV, Ryan would play a pleasant, dotty mom who finds herself working for her former intern at a New York publishing house.
As our heroine tries to please her new boss, her teenage children, her estranged husband and her mother-in-law, she overcomplicates everything and generally makes matters worse.
Marc Lawrence (Miss Congeniality, Family Ties) will write the script and executive-produce with Ryan and her manager Jane Berliner.
Before she became a rom-com sweetheart in films like Sleepless in Seattle and You’ve Got Mail, Ryan began her career on the CBS soap As the World Turns. Her recent (and rare) TV appearances include Web Therapy and Curb Your Enthusiasm.