TVLine Items: Neil Patrick Harris Fills In on Live!, Anna Kournikova Leaves Loser and More!

Neil Patrick Harris is the second celeb set to fill in for Regis Philbin, who later this week makes a permanent exit from Live! with Regis and Kelly.

The How I Met Your Mother star has been named guest co-host of the daytime talkfest for the week of Nov. 28. As previously announced, Jerry Seinfeld will be the first to occupy Philbin’s vacant seat beginning Nov. 21.

Ready for more of today’s TV dish? Well…

• Anna Kournikova is leaving The Biggest Loser after just one season as a trainer, per The Hollywood Reporter. The tennis star joined the NBC weight loss series for its 12th cycle (which is currently airing on Tuesdays at 8/7c) as a replacement for Jillian Michaels.

• Megan Mullally has landed a guest spot on NBC’s Up All Night, E! Online reports. The ubiquitous funny lady will play a rival of Maya Rudolph’s Ava.

• Fresh off her stint on the short-lived Playboy Club, Laura Benanti will appear on NBC’s Law & Order: SVU as the estranged wife of the department’s new detective, Nick Amaro (Danny Pino), per TVGuide.com.

• 30 Rock‘s Best Friends Gang is back in action! Kelsey Grammer, playing Kelsey Grammer, will reunite with his cake-scamming buddies Kenneth and Jenna in a Season 6 episode of the NBC comedy, TV Guide Magazine reports. The Boss star first appeared in an Oct. 2010 installment.

Mad Men‘s Kiernan Shipka will play herself in an episode of ABC’s midseason comedy, Don’t Trust the B—- in Apartment 23, per EW.com.

Which TVLine Items have you talking today?