Both actresses will be part of an Amazon pilot written by, directed by and starring comedic actor Jay Chandrasekhar, our sister site Deadline reports.
Chalke and Chandrasekhar will play married couple Lori and Jed, who are at the center of a group of 30-something friends in Chicago.
Blair’s role is Joanna, wife of Luka Jones’ (Up All Night) Fred. The potential series’ conflict comes when Jed catches another friend, Mike (Travis Schuldt, Scrubs), having an affair with Joanna.
Chalke’s sitcom How to Live With Your Parents (For the Rest of Your Life) met an untimely end on ABC last year; her other TV credits include Scrubs, Roseanne, Grey’s Anatomy and How I Met Your Mother.
Blair made news last summer when she abruptly left FX’s Anger Management during its 90-episode second season. She previously appeared in Web Therapy, Kath & Kim and Zoe, Duncan, Jack and Jane, among other series and feature films.Follow @kimroots