Singer Miguel will be the musical guest that evening.
The episode will mark Vaughn’s second hosting stint; the first came in 1998.
After getting his big break in Swingers, Vaughn’s prolific career has included comedies like Wedding Crashers, Anchorman: The Legend of Ron Burgundy, Old School and Couples Retreat.
NBC also confirmed that Mike & Molly star Melissa McCarthy will host the April 6 outing with musical guest Phoenix.
How do you think Vaughn and/or McCarthy will compare to Justin Timberlake’s performance last week? Sound off in the comments!Follow @kimroots