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Exclusive: House's Jesse Spencer Talks Next Week's Momentous Episode, Touts 'Nice Payoff'

“The last eight seasons has been building up to this,” declares Jesse Spencer of next week’s pivotal House (Fox, 8/7c), which finds Hugh Laurie’s titular doc under fire when his controversial process blows up in his face like never before.

“The episode covers a specific diagnosis of a patient that goes horribly wrong,” adds Spencer. “Most of it is with our examiner [special guest star] Jeffrey Wright asking questions of the team [as well as] House and trying to ascertain who is at fault.”

And while much of the attention surrounding this episode has (understandably) focused on the onscreen showdown between Laurie and Wright, executive producer Greg Yaitanes (who directed the episode), says it’s also a big outing for Spencer, noting, “Jesse has a phenomenal opportunity in this episode to really make us as the audience take pause.”

“It explores a [different] side of Chase, who ends up mixing his work life and his personal life,” Spencer elaborates. “It really does get entangled. We watch him get deeper and deeper into it with a really nice payoff.”

For more from Spencer and Yaitanes — and to view an exclusive preview from Monday’s episode, “Nobody’s Fault” — press play below. And then scroll down further for a second clip focused on Wright’s explosive guest turn.